I have heard of people being allergic to hedgies and there is a few people on this forum that are if I remember right. Sometimes it can be from just holding them and sometimes it happens when the quills poke the skin and will cause a reaction. I'm not allergic to hedgies but from being allergic to other things outdoors and some animals I just use Benedril Cream for skin reactions and hives and if its something that is worse then I take Benedril Pills (you'll want to clear it with your doctor first, this is just what I was told to use from mine as an over the counter fix). There is certain things I'm pretty severly allergic to and the Benedril clears it up.