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I've seen people report hedgehogs who have had mammary cancers removed, margins were clear, and the hedgehog lived a good long life afterwards... Others have had it reappear but in a different location. It really just depends on the cancer and the hedgehog, much like it does in humans I suppose. Early removal (with clean margins) is likely the best we can hope for getting a long life afterwards.

We had one removed from a rescue once, margins were unclean yet she lived another year before developing colon cancer.

Whenever I have on that has had cancer, I always start monitoring them regularly for any new lumps or health changes. And get them checked out quickly if you see anything new.
 
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