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What bedding is he on? If shavings or carefresh, try switching to liners. Often it is the bedding that causes the reaction as it gets poked into the skin by his quills.

Bathing more often sometimes helps but it can also make it worse if you use a shampoo. It's best to bath with plain water.

I have a few that give me a reaction and it doesn't matter if they are clean or dirty. I keep a container of baby wipes handy and wipe my hands and skin often while handling those ones.
 
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