Don't take her out several times a day. Stick to one schedule, probably sometime in the evening, when you can handle her for a set amoutn of time. Usually having a schedule helps your hedgie be less grumpy at that time since they know when you'll be coming around to play with them.
Imagine yourself as the hog. If you were trying to get a good night's (err day's?) sleep, would you like being woken up several times throughout the night (day)? Probably not. I find my hogs tend to be friendlier at night, or at least after the sun sets. Handling Kashi in the morning? Forget about it!
He is the most mellow guy ever, but disturb his beauty sleep and you will have a temper tantrum on your hands