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Old 08-22-2008, 07:52 PM   #1 (permalink)
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Default Ivermectin injection goes bad

This was posted by alberta...

Hi, Our hedgehog Gaunchy passed away last night. He was an amazing little guy, almost 5 years old. Very surly and lovable.

He had been in good health , other than a bad case of mites. I took him to the vet to get a shot of ivermectin. The first injection went fine, he didnt mind, the vet delivered the injection sub Q into his belly.

The second injection a week later went really bad. Gaunchy was in a tigh ball and didnt want the shot. I tried to pry him apart but could not. So, the vet gave the injection into his rump on the quill part of his back. Immediatly he started to open and close his mouth and you could tell he was in pain. And blood was seeping from his mouth a little bit. (This may have been from a broken tooth??) . I took him home, the gasping continued for an hour or so.

I took him back to the vet who then gave him some steroids and one other shot, this time in the belly because he was very week and sprawled out by then. I was told he had fluid in his lungs and his heart beat was irregular. Again I took him home.

Over the next week he began to walk again (with a stagger), and to eat and drink in an awkward fashion . We thought he might pull through. Then last night he began to cry out loud (I had never heard him do that), he lost control of his bladder and took his final nap.

I was wondering if you had any clue what might have brought this about??? The vet really is not sure and thought maybe he had a stroke from the trauma of me trying to open him up for the injection? I thought maybe his tooth broke off and he swallowed it. The tooth I noticed missing after the last shot. But it may have been gone before that, Im not sure.

If anyone had any thoughts on this I'd like to know, so I could share it with the vet too, he is also very concerned about what occured. Thank you for your time

Sincerely,
J.B.
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Old 08-22-2008, 07:53 PM   #2 (permalink)
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Default Re: Ivermectin injection goes bad

Posted by shmurciakova...

I am really sorry to hear that this happened to your little guy!
It is not the first time I have heard this - you can look back through the old posts and read other stories of hedgehogs dying from Ivermectin. It used to be the common treatment but it is very easy to overdose a hedgehog. I implore you to print out some information on the dangers of Ivermectin to give to your vet and let them know about Revolution. It is not an injection, it is a one time topical treatment. Just Google Revolution and hedgehog mites and you should come up with something.
Once again, so sorry to hear your story. He sounds like such a sweet boy. The vet really needs to be notified so this does not happen to anyone else.
My condolences,
Susan. sad.gif
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Old 08-22-2008, 07:54 PM   #3 (permalink)
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Default Re: Ivermectin injection goes bad

Posted by Bryan....




I am SO sorry to hear this happened!!

Ivermectin stings horribly when injected, so he probably remembered the first injection and refused to unroll. Although the injection may not have been the direct cause of death, it was likely the instigating factor.

In 13 years of breeding we have only ever treated hedgehogs with Ivermectin when we had to ship them into the USA. Given the option, we wouldn't even do that, but USDA insists for hedgehogs entering their country.

Consider it - you are giving an internal injection to control external parasites!

Essentially, Ivermectin works by modifiying the gamma-aminobutyric acid (GABA) in the central nervous system of mammals. In nematodes and arthropods, GABA sends inhibitory signal to motor neurons by activating these inhibitory signals, resulting in the paralysis of the parasite. The claim is that GABA is confined to the central nervous system in mammals and thus does not cross the blood brain barrier, but this is disputed. If given to a pregnant mammal during pretty much any time during gestation, the fetus is often killed or malformed.

Over the years there have been SEVERAL cases of Ivermectin being the direct or indirect cause of hedgehog death as well as some suspicious deaths. The veterinarian profession claims time and time again that Ivermectin is completely harmless, but rather than investigate, they try to blame the deaths on secondary causes.

We use a mild flea and tick spray to control mites. It's an external treatment that controls external parasites. We use the same spray to treat the cages, nest boxes, etc, as well. It works extremely well and we've haven't had a single sick hedgehog as a result, let alone one that died.

If we want to treat them for worms, we give them an oral Albendazol wormer. It's extremely safe and the hedgehogs like the taste of the stuff.

I've said it before and I'll say it again, don't use Ivermectin to control mites!
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Old 08-22-2008, 07:55 PM   #4 (permalink)
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Default Re: Ivermectin injection goes bad

Posted by Kalandra...

Bryan,

What is your opinion of using Ivermectin as a topical treatment? I've talked to Standing Bear about using the topical variety in depth in the past.. inquiring about his experiences and what Dr. Dressen thought about Revolution. So I'm curious to see what others think of the topical application.

In case others didn't know, Ivermectin is usually given as an injectable, however there are oral and topical applications. Some vets only give the injectable, others will give the other two. The oral solution has a rather bitter taste making it difficult to give.

I think a lot of the problems that have occurred from Ivermectin are from vets who gave an overdose. The dose required for a big hedgehog is pretty small.

As a side note: I found an article recently discussing using Ivermectin in humans (stromectol).
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Old 08-22-2008, 07:56 PM   #5 (permalink)
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Default Re: Ivermectin injection goes bad

Posted by Bryan...

The topical Ivermectin is certainly less invasive than the injectable. I’ve heard of some skin irritation and quills or fur loss in the immediate area of the application, but nothing more. It still works the same way, though – it is absorbed into the central nervous system where it affects the GABA.

Revolution appears to be safer and we’ve had actual trials with Revolution being used on hedgehogs that were quite successful.

All that said, however, I still prefer to spray wink.gif


Bryan
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Old 08-22-2008, 07:57 PM   #6 (permalink)
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Default Re: Ivermectin injection goes bad

Posted by Vern...

We used oral Ivermectin once with my lil gurl Baby (pictured). It very nearly killed her, she became utterly unresponsive to anything and refused to eat or drink. Needless to say I was one very distraught hedgie daddy.
We nursed her back to health with round the clock feedings and waterings ... following Jeannes counsel.

Some purport Ivermectin to be safe, my experience says otherwise. We'll never use it again, nor will I ever recommend it.

Vern
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Old 08-22-2008, 07:59 PM   #7 (permalink)
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Default Re: Ivermectin injection goes bad

Posted by HedgieMate...

I've read some people using Ivermectin topically -- they too believe topical applications are "less risky" than oral or injected applications. I've never had any first hand experience with mites or parasites, let alone Ivermectin (touch wood), so I don't know the answer to your question. unsure.gif However, what we have to remember is that hedgehogs self-anoint. I don't know if Ivermecin has any scent, but if it does, the chances are that hedgies will self-anoint with it. Personally, that seems risky since you have no idea how much your hedgie will lick Ivermectin off his/her body.

Do you know Ivermectin is used on humans as well, as a dermatologic treatment? I found a research paper on the internet posted by someone at McMaster University in Canada on the subject. The paper documented a few fatal cases among their elderly patients. Deaths linked with Ivermectin among cattle have been also reported in a number of research papers as well. These facts alone make me very apprehensive about Ivermectin. "Why take chances if you could avoid it easily?" is my personal feeling on the issue.
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Old 08-22-2008, 08:00 PM   #8 (permalink)
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Default Re: Ivermectin injection goes bad

There are many people who have hedgehogs that have had ivermectin treatments with no harmful effects. Topically seems to be safer than injection but I think it was Vern that had one with a reaction to it taken orally. There have been way too many deaths to make ivermectin something that I would ever risk using.

The worst reaction I've heard of a hedgehog having to revolution was some skin irritation at the area of application.

So, we have ivermectin whose possible side effect is death, versus Revolution whose possible side effect is skin irritation. Guess what I'd go for.
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Old 08-22-2008, 08:02 PM   #9 (permalink)
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Default Re: Ivermectin injection goes bad

Ivermectin can be used either through injection, topically or orally. The majority of problems with it are caused by injection but there are still reactions to both topical and oral applications. Ivermectin is only safe if a very precise dosage is given. Even when done precisely there are adverse reactions to it and these adverse reactions are very often death.

I really don't understand why anyone would take the risk with ivermectin when Revolution is readily available and is SAFE! The whole reason Revolution can be given in a non precise drop is because it is so much safer and a drop of any size is not going to cause an overdose.

I would never allow ivermectin to be used on our hedgehogs but for those who feel it is necessary, why resort to injecting it when topical works just as well and is not invasive. Of course a hedgehog is going to ball up when injected and the second and third dose especially since they know whats coming. I firmly believe injecting ivermectin is not only unsafe but cruel when there are other safe and less stressful methods and products that can be used.
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Old 09-24-2008, 07:36 AM   #10 (permalink)
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Default Re: Ivermectin injection goes bad

I'm bumping this up as there seem to be a lot of hedgehogs needing mite treatment having ivermectin used on them.

Read this thread about ivermectin reactions.
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